Poster Presentations by BonePainII Students at the OARSI 2022 World Congress on Osteoarthritis

Stephania Kalegora, a BonePainII PhD student based at the Danish company Nordic Bioscience, had a poster presentation at the OARSI conference in Berlin 7-10 April 2022.  The title of her poster was “A Noval Cathepsin K Mediated Fragment of C-Reactive Protein As a Biomarker for Bone Inflammation”. 

Together with colleagues from Nordic Bioscience Stephania presented a newly developed biomarker designed with the neo-epitope technology from Nordic Bioscience, which is a fragment of CRP protein generated by cathepsin K. This fragment has been shown to be elevated in patients with ankylosing spondylitis and is supposed to reflect bone inflammation related to inflammatory bone marrow lesions. 

The main idea behind the development is that when CRP is accumulated to the inflamed tissue it can be post-translationally modified from the secretion of the different proteases released from the joint. Cathepsin K is mostly secreted by osteoclasts and can cleave CRP and generate a neo-epitope fragment which can be quantified in serum.  

Her fellow PhD student at Nordic Bioscience, Khaled Mohamed, also presented a poster at the conference. ‘

  • Stefania Kalogera and Khaled Mohamed, BonePainII PhDs students at Nordic Bioscience with colleagues from Nordic Bioscience

  • Stefania Kalogera; BonePainII PhD student at Nordic Bioscience